Paper Type |
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Research Paper |
Title |
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New sampling method for routine monitoring of selected pharmaceuticals in surface water |
Country |
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China |
Authors |
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Marek Mucha ||, Jiří Kalina |
Page No. |
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35-45 |
 |
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 |
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3021-0510-0245  |
The surface waters contain trace levels of pharmaceuticals therefore powerful analytical methods and/or extraction pre-treatment of samples are necessary. But these methods are very expensive and their utilization is therefore limited especially for nonprofit ecological organizations. The aim of this study was to develop a cheap sampling method for routine monitoring of Ibuprofen, Cyproteron acetate, Desogestrel, Ethynilestradiol and Gestodene contents in aquatic environment. The sampling method was developed for sample collection and for concentration enrichment. Proposed sampling method is based on utilization of bags filled with crushed dried Reynoutria Bohemica which were tested by sorption and desorption experiments with model aquatic samples. The sorption capacities were determined from 37.5 to 77.5 mg/g. The optimum desorption conditions were determined (desorption efficiencies from 60.2 to 94.3%). Two UHPLC/MS methods were developed and validated for determination of pharmaceuticals concentrations. Obtained validation parameters enable utilization of these methods for analysis of trace levels of above-mentioned pharmaceuticals. Developed sampling method was applied to monitoring of studied pharmaceuticals contents in surface waters of Moravian-Silesian Region (Czech Republic). The contents of above-mentioned pharmaceuticals in studied waters were established in tens ng/g/24h. It can be stated that proposed method is suitable for routine sampling of surface waters.
Keywords: Liquid chromatography; Mass spectrometry; Pharmaceuticals; Sampling, Water contamination
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